The focus of her rage is Universal Pictures, who snapped up a script about the singer's early years in New York earlier this week.
Madonna sought out a copy of the screenplay, called Blonde Ambition, and immediately declared it to be "all lies".
"Nobody knows what I know and what I have seen," the 58-year-old fumed on Instagram.
"Only I can tell my story. Anyone else who tries is a charlatan and a fool.
Looking for instant gratification without doing the work. This is a disease in our society."
Penned by first-time writer Elyse Hollander, Blonde Ambition topped last year's Black List, Hollywood's annual chart of the best unproduced screenplays.
The list has previously featured future Oscar-winners such as Spotlight, The Revenant, Argo and American Hustle - so it's no surprise that Universal nabbed the rights.
Two major producers have already been attached to the project, Michael De Luca (The Social Network) and Brett Ratner (X-Men), who himself directed Madonna's Beautiful Stranger video in 1999.
However, it's clear that the project doesn't have the star's approval.
In theory, that's not a barrier to the film getting made, but the script relies heavily on Madonna's music, including Like A Virgin, Everybody and Lucky Star.
If the singer vetoes their use, the project would essentially be dead in the water.
But how inaccurate is Hollander's script?
We read a publicly available draft to see how closely it stuck to Madonna's story.
While the arc is broadly true, Hollander compresses and condenses events, even creating composite characters to keep up the momentum.
Here's what's true, and what isn't.
The first act of the script focuses on Madonna's pre-fame band The Emmys, which she formed with her boyfriend Dan Gilroy and childhood friend Stephen Bray, who went on to co-write Into The Groove, Express Yourself and True Blue.
Their name derived from Madonna's childhood nickname, and video footage of their scrappy garage tunes can easily be found online.
The film insists the group were a cheap knock-off of new wave pop band Blondie, but their sound was more indebted to Britain's ska and 2 Tone scenes.
Madonna can even be heard adopting a British accent in some of their early demos.
Madonna's most public mishap came at the 2015 Brit Awards, when she was yanked off stage by a cape.
But it had happened once before - at the first MTV Awards in 1984, when she lost a stiletto while walking down a 17ft (5m) tall wedding cake in her wedding dress (it could happen to anyone).
Although the incident plays a pivotal part in Blonde Ambition - has she lost the baby? - it was never as serious as the script makes out.
"I thought, 'Well, I'll just pretend I meant to do this,'"
Madonna later said. "So I dove on the floor and I rolled around. And, as I reached for the shoe, the dress went up. And [my] underpants were showing."
The stumble-flash made television history and propelled Madonna to even greater heights. And that's where the film drops the curtain.
