The 53-year-old actor - who recently split from Amber Heard after just over one year of marriage - has listed the spacious property in Downtown LA for $12.78 million.
Johnny's home is in the Eastern Columbia Building and is comprised of five adjacent penthouses, which the actor kept largely separate, living in them "like rooms in a home," his real-estate agent Kevin Dees of Partners Trust told the Wall Street Journal.
He connected three of the units via doorways but left two separate, using one as a studio and another as a guest suite.
The units can be bought separately or together.
This comes less than two months after it was revealed that Johnny is selling his mansions in France and Venice.
Johnny recently doubled the asking price on his French compound, which is set on 37 acres of land and boasts more than a dozen buildings.
He first put it up for sale last year, with an asking price of around 23 million euro but took it off the market a few months later.
Now it's back on for twice as much and it is being sold fully furnished with DVDs still on the bookshelves.
As well as all the buildings, it comes with two swimming pools, a gym, a skate park, a restaurant with a professional kitchen, a launderette and a garage.
A church on the site has been converted into a guest house with the confession box converted into a wardrobe.
Alexander Kraft, chairman of Sotheby's International Realty France, who previously listed the property, said: "Johnny had decided to sell the Plan de la Tour property to close this chapter of his life and move on.
"He hopes that someone else will enjoy the property as much as he did and bring him or her the same happiness it brought."
And he is selling his Venetian mansion for almost 11 million euro.
The 'Pirates of the Caribbean' star put the seven-bedroom palace on the market five years after purchasing the plush property which overlooks Venice's Grand Canal.