The 30-year-old star has appeared to suggest her new track 'Perfect Illusion' is about the break up of her relationship with the 'Chicago Fire' actor.
She explained: "It is about love. Of course it is. It is about all kinds of relationships, every kind of love in your life and mine. And I think it's both sides - it's not really from the woman's perspective this song - it was important to me that men, when they heard this song, felt connected to women even though the song is essentially about a barrier between us.
"The song essentially is about how I believe that many of us are wondering why so many fake things that are around us appear to be real. They appear to be so real and it's almost impossible to decipher anymore what is authentic and what isn't."
The 'Bad Romance' hitmaker admits she finds it difficult to meet new people.
She added: "It's not that easy to meet new people, no, like just strangers which I miss, I do. I will also be good speaking to strangers, which is really not a thing to teach to children, I find people interesting. I still make friends; it's just not like it used to be I guess."
Meanwhile, Gaga also revealed the song has a second meaning - the facade of social media.
She told The Sun newspaper: "You're scrolling through social media or going through Instagram and you're overloaded with things that are filtered and in a way I believe that that has seeped into personal relationships, dating and friendship, so what's happening is we're trying to establish human connections but we're doing it through falling in love with a perfect illusion. So I say in this song, 'dilated falling free in this modern ecstasy', and that's what 'Perfect Illusion' is all about."