The pop icon was at the prestigious photography exhibition for Mert Alas and Marcus Piggot last week and fellow guests couldn't believe it when she started sprawling along the ground while clutching a glass of wine.
One told The Sun Online: "Madonna was stumbling around. She had somebody with her who looked like a bodyguard. He didn't want people to take pictures.
"I didn't speak to her but my friend did and he told me she was very merry. It was completely unexpected, I was a bit surprised to see her.
"The bodyguard didn't want her to be photographed but she didn't seem to care at all. She was fooling around on the floor. She was turning around on her back and then she sat up."
Lots of guests loved seeing Madonna letting her hair down and relaxing.
Another added to us: "She was having a laugh and some fun."
And the mother-of-four's fun didn't stop there.
Later on she joined the likes of Naomi Campbell and Kate Moss at Edward Enninful's star-studded dinner with catwalk queen Kate Moss.
At the exclusive Marks venue in London, Madonna, 58, started grinding up and down a pole.
She then posted lots of pictures on her Snapchat channel, where she appeared to be rather tipsy as she attempted a selfie with supermodel Kate.