The 'Send My Love' hitmaker will reportedly celebrate the annual holiday, which takes place on November 24, with the 'Hunger Games' star and her family in Los Angeles despite also receiving invitations from songwriter Ryan Tedder and Robbie Williams and his wife Ayda Field.
A source told the Daily Mirror newspaper: "Adele wants to really throw herself into the American life now that she has a base here. Her plans to get to grips with the Thanksgiving celebration which is a far bigger deal than Christmas in the States.
"Jen wants to show her the real family treat. She wants to throw a party at her pad, having her family fly in to give it a proper family feel."
Meanwhile, Adele's partner Simon Konecki - with whom the singer has three-year-old son Angelo - will split his time between Los Angeles and the UK.
An insider shared: "Adele and Simon's relationship is as strong as ever but it's a little unusual as they have always moved between a number of houses.
"Simon has a lot of work in the UK and of course another child so he's still going to be based here for a lot of the year."
Adele is currently in the midst of her world tour and recently claimed her voice has "weakened" ever since she quit smoking.
She said: "The people with the best voices, they always smoke. I've given up smoking and I'm convinced that's made my voice weaker. Bruno Mars smokes like an old woman. My make-up artist will stink after having a fag. I had never noticed it before."