The 24-year-old singer has beat the likes of her friend Taylor Swift, who has 91.4 million fans on the site, Beyoncé, who has accumulated 85.3 million, and Kim Kardashian West, who has 83.6 million, to be crowned queen of the popular social networking website.
The brunette beauty's impressive milestone will no doubt come as a surprise to her as she's managed to claw her way to the top despite being inactive online for the past six weeks.
However, she's no stranger to success on the photo-sharing app as she previously broke the record for the most 'likes' on a photo when she shared a shot of herself sipping Coca-Cola through a straw and 4 million people hit the tiny heart symbol on the site.
Since she posted that seductive photo 13 weeks ago, it's managed to top its record-breaking 'likes' and is now on 5.6 million at time on publish.
Meanwhile, the 'Hands to Myself' hitmaker's absence on Instagram comes just a few weeks before she announced she was taking a break from her career to focus on her health.
Selena has been battling with anxiety and depression as a result of the chronic inflammatory disease lupus and feels the only way to get the condition under control is to focus on herself.
She said recently: "As many of you know, around a year ago I revealed that I have lupus, an illness that can affect people in different ways. I've discovered that anxiety, panic attacks and depression can be side effects of lupus, which can present their own challenges.
"I want to be proactive and focus on maintaining my health and happiness and have decided that the best way forward is to take some time off.
"Thank you to all my fans for your support. You know how special you are to me, but I need to face this head on to ensure I am doing everything possible to be my best. I know I am not alone by sharing this, I hope others will be encouraged to address their own issues."